CHD is usually associated with genes necessary for heart development, and in patients with non-syndromic CHD, it is likely to be involved in transcription factors (TBX1, FOG2, GATA4, NKX2.5, etc.)or signaling pathways (FOXH1, VEGF, NODAL, NOTCH1, etc.)that may disrupt cardiac morphogenesis [19]. The gene discussed is NKX2-5; the disease is coronary artery disorder.