TF and Patent ductus arteriosus: In this study, (1) we found a total of 13 variants in this region, and 10 of these variants were found only in PDA patients; (2) all the variants found in PDA patients significantly altered the expression of the CITED2 gene; and (3) these variants played a role in the development of PDA by affecting the binding ability of the promoter to the TF or by altering the TFBs on the promoter.