TGFB1 and systemic sclerosis: IL11 is presumably more than just a biomarker as IL11 plays a central role in mediating the fibrotic activity of TGF-β [19,20], for instance, in cardiovascular and pulmonary fibrosis [33,34] as well as systemic sclerosis [35], non-alcoholic steatohepatitis [36], and kidney dysfunction [37].