Considering the results described above and earlier reports from our lab, as well as previous studies from different countries, which confirm that low serum amylase activity is coincident with DT2 and obesity [4,5,6,7,8,9,10,11,12], we suggest that a revision of the descriptions/meanings of insulin resistance vs. insulin sensitivity is needed. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.