CHI3L1 and Hepatic fibrosis: Additionally, CHI3L1 plays a crucial role in liver fibrosis by directly affecting hematopoietic stem cells [93,94], which is corroborated by the results of Masaaki et al. [95], who found that CHI3L1 deficiency significantly reduces the level of liver TGF-α but does not affect the level of TGF-β and that CHI3L1 is involved in the apoptosis of liver macrophages by mediating Fas expression and the Akt signaling pathway.