In the invasive pulmonary aspergillosis (IPA) model, pentoxifylline (PTX) significantly inhibits CHI3L1 expression in non-neutropenic IPA mice (HC-IPA) [127], suggesting that CHI3L1 may also be a potential target for fungal infection and inflammation in the brains of AD patients, which is worth further exploration by researchers. This evidence concerns the gene CHI3L1 and Ito hypomelanosis.