As early as 2011, Francescone et al. found that CHI3L1 can promote glioblastoma angiogenesis and radioresistance [152], while Chen et al. found that silencing CHI3L1 can inhibit the VEGF/VEGFR and ERK1/2 signaling pathways, further reducing tumor angiogenesis and inhibiting tumor metastasis [153]. This evidence concerns the gene MAPK3 and neoplasm.