Thus, the activation of Wnt signaling, STAT3, Rho GTPases, ROCK kinase, FAK, the regulation of the EMT pathway and the upregulation of LEF1 protein collectively might contribute to cytoskeletal reorganization, cell trafficking, and enhanced cell motility, and highlight the complicated network of molecular events involved in the invasive behavior of tumor cells. The gene discussed is LEF1; the disease is neoplasm.