POU5F1 and digestive system neoplasm: Namely, LEF1 is part of the Wnt/β-catenin signaling pathway, which includes for example genes such as c-Myc, LBH, Oct4, NANOG that have been associated with the upregulation of proteins typically involved in human breast cancer, gastrointestinal tumors, prostate cancer, leukemia, and others [20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35].