MMP2 and colorectal carcinoma: As we have found, WNT6, highly conserved in various species, with a highly increased expression, and mainly considered to be a member of the β-catenin-dependent Wnt signaling pathway [52], might increase the proliferative ability of colorectal cancer cells (CRC), leading to increased expression of MMP2, which is also involved in the breakdown of the extracellular matrix [53].