In PAD patients, short administrations of clopidogrel can reduce the expression of adhesion molecules such as p-selectin and CD63, as well as regulate upon activation, normal t cell expressed and presumably secreted (RANTES–CCL5), modulating the adhesion of platelets [56] and the recruitment of leukocytes into vessel walls [119] (Table 1). This evidence concerns the gene CCL5 and peripheral arterial disease.