ACE and heart failure: Angiotensin-converting enzyme inhibitors (ACE-i), angiotensin receptor blockers (ARBs), and angiotensin receptor neprilysin inhibitors (ARNI) are all medications widely employed in the cardiovascular field for a variety of conditions (hypertension, proteinuria, and heart failure), and all target the renin–angiotensin–aldosterone system (RAAS) and neprilysin.