On the other hand, MIF promotes the uncontrolled proliferation of keratinocytes in murine models of psoriasiform dermatitis, inflammatory cell infiltration with monocyte-derived cells, and dermal angiogenesis [153], suggesting its role as a disease promoter in psoriasis and as a linking molecule between psoriasis, obesity, and IR. The gene discussed is MIF; the disease is obesity due to melanocortin 4 receptor deficiency.