When analyzing the DEGs using the bioinformatic platform Enrichr-KG [46], the most relevant transcription factors potentially driving the differences in kidney gene expression between COVID-19 AKI and non-COVID-19 AKI were POLR2L, EIF3K, BOLA3, RFXANK, and ZNF576 (Figure 3). The gene discussed is RFXANK; the disease is acute kidney injury.