Some of the proteins that were identified have been implicated in well-established morbidities associated with OSA, such as coronary artery disease (PLAT, APOB, APOA1, APOE, PCSK9, LPA), lipid metabolism disorder (APOC3, APOB, APOA1, APOE, LCAT, PCSK9, LDLR), vascular disease (PLAT, SERPINE1, APOB, APOA1, APOE, PCSK9, LPA), atherosclerosis (APOB, APOA1, APOE, LPA), and neurodegenerative disease (APOE, SORL1, APP, BACE1, MAPT, TREM2, VLDLR). This evidence concerns the gene BACE1 and obstructive sleep apnea syndrome.