Brauneck et al. previously reported an increase in the NK-cell-mediated lysis of AML cells (MV-4-11, TF-1, and OCI-AML3) by blocking A2AR in the NK-92 cell line in vitro, which was more notable after the combinational blockage of A2AR and TIGIT [47]. This evidence concerns the gene RUNX2 and acute myeloid leukemia.