Various isoforms of proteinase inhibitors involved in the regulation of coagulation and inflammation, such as kininogen 1 (A0A060WI78), alpha-2-macroglobulin (A0A060WW01), inter-alpha-trypsin inhibitor heavy chain 3 (A0A060YKA6), complement C1r-A subcomponent (A0A061A8T0), and serpin domain-containing proteins alpha-2-antiplasmin (A0A060XQ45) and alpha-1-antitrypsin (A0A060XWS9), were less abundant in plasma with high antimicrobial activity, whereas the endopeptidase inhibitor protein AMBP and complement C4-like protein were found to be up-regulated in AP. This evidence concerns the gene ITIH3 and alkaline phosphatase measurement.