Also, the supplementation with betaine and miR-143 knockout caused obesity attenuation due to the repression of the glycoprotein nonmetastatic melanoma protein B (GPNMB), which has been reported to promote lipogenesis in white adipose tissue (WAT) and intensify diet-induced obesity [47,54]. The gene discussed is GPNMB; the disease is obesity due to melanocortin 4 receptor deficiency.