Taking into account the pivotal role of MLH1 methylation in the current flow charts for LS identification [5,8,18,19,20,21], in this study, a series of 61 cancers including 31 CRCs, 27 ECs, 2 ovarian cancers and 1 stomach cancer were studied in order to investigate the involvement of MLH1 promoter hypermethylation in cancers of patients suspected for Lynch syndrome. This evidence concerns the gene MLH1 and ovarian carcinoma.