Taking into account the pivotal role of MLH1 methylation in the current flow charts for LS identification [5,8,18,19,20,21], in this study, a series of 61 cancers including 31 CRCs, 27 ECs, 2 ovarian cancers and 1 stomach cancer were studied in order to investigate the involvement of MLH1 promoter hypermethylation in cancers of patients suspected for Lynch syndrome. The gene discussed is MLH1; the disease is gastric neoplasm.