Finally, in family F-6 (Figure 4b), a young woman (P-38) who was a carrier of a variant of uncertain significance (VUS) in PMS2 c.2380C>T p.(Pro794Ser), was affected by a CRC, with a high level of MLH1 hypermethylation that was also confirmed in the blood sample. The gene discussed is PMS2; the disease is colorectal carcinoma.