MAPT and amyotrophic lateral sclerosis: In addition, complex inversion 673 bp region of MAPT H2 haplotype can reduce the risk of FTD/ALS but also AD, LBD, and PD [34,91,92], while several identified deleterious SVs encompassing the MAPT gene region and H1/H2 haplotype could be implicated in the gene expression [34,51].