NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most prevalent hereditary stroke condition attributed to mutations in the neurogenic locus notch homolog protein 3 (Notch-3) gene and serves as a significant contributor to VaD [20].