APOE and Alzheimer disease: Beyond the primary risk factors like age, family history, and the APOE4 genotype [13], late-onset AD is also influenced by additional risk factors, such as triggering receptor expressed on myeloid cells-2 (TREM2), a disintegrin and metalloproteinase 10 (ADAM10), and phospholipase D3 (PLD3), that not only impact APP and tau but also play a role in cholesterol metabolism and immune response [14,15].