Since the truncating variants in FLNC are highly enriched in an overlapping phenotype of dilated and left-dominant arrhythmogenic cardiomyopathy [56], missense variants, especially those located in the ROD2 domain, have recently been associated with HCM and restrictive cardiomyopathy phenotypes [22,57,58]. The gene discussed is FLNC; the disease is restrictive cardiomyopathy.