TARDBP and amyotrophic lateral sclerosis: The most relevant studies showed the pathological hallmarks of TDP-43 mutation in ALS, which include nucleus-to-cytoplasmic mislocalization, the deposition of ubiquitinated and hyper-phosphorylated TDP-43 into inclusion bodies, protein truncation leading to the formation of toxic C-terminal TDP-43 fragments, and protein aggregation [25,26].