While alterations of TP53 and CDKN2A/PTEN have been reported in GATA3-positive PTCL-NOS, associating with complex chromosomal rearrangements and genomic instability, these alterations appear to be infrequent in ATL and AITL [68]. This evidence concerns the gene PTEN and mature T-cell and NK-cell non-Hodgkin lymphoma.