MC4R and obesity due to melanocortin 4 receptor deficiency: Findings on an elevated risk of obesity among females compared to males can be explained by the findings of Horstmann et al., who demonstrated an increased ‘emotional eating’ score of the MC4R rs17782313’s variant risk allele carriers and suggested that the MC4R rs17782313 effect on eating behavior is mediated by central mechanisms that are sex-specific [59].