Subsequently, we conducted clustering and LASSO analysis on each tumor and found that the inhibitory and the stimulating immune checkpoints positively correlate with <i>ZBP1</i>, <i>NLRP3</i>, <i>CASP1</i>, <i>CASP8</i>, and <i>TNFAIP3</i>. The gene discussed is ZBP1; the disease is neoplasm.