<i>IRF6</i> rs2235375 showed a significant association with an increased risk for non-syndromic cleft lip and palate (NSCLP) and cleft lip with or without cleft palate (NSCL/P) in the G allele, with p<sub>allele</sub> values of 0.0018 and 0.0003, respectively. Here, IRF6 is linked to cleft lip.