Other variants (BRCA2 (c.5900A>G; p.(Lys1967Arg)), ATM (c.1810C>T; p.(Pro604Ser)) and MET (c.2962C>T; p.(Arg988Cys)) were found in non-syndromic patients (3/74; 4%) with clear cell renal cancer before 50 years of age. Here, MET is linked to clear cell renal carcinoma.