The major genes are VHL (OMIM * 608537), FH (OMIM * 136850), MET (OMIM * 164860), and FLCN (OMIM * 607273), involved, respectively, in Von Hippel–Lindau (VHL) disease, hereditary leiomyomatosis and renal cell carcinoma (HLRCC), hereditary papillary renal cell carcinoma, and Birt–Hogg–Dubé (BHD) syndromes. This evidence concerns the gene FLCN and hereditary leiomyomatosis and renal cell cancer.