The major genes are VHL (OMIM * 608537), FH (OMIM * 136850), MET (OMIM * 164860), and FLCN (OMIM * 607273), involved, respectively, in Von Hippel–Lindau (VHL) disease, hereditary leiomyomatosis and renal cell carcinoma (HLRCC), hereditary papillary renal cell carcinoma, and Birt–Hogg–Dubé (BHD) syndromes. Here, FH is linked to hereditary leiomyomatosis and renal cell cancer.