In a Danish cohort including 49 patients from 48 families with a suspected hereditary risk of renal cancer, Christensen et al. found no pathogenic variants in RCC causative genes (VHL, FH, FLCN, MET, BAP1, SDHB) and one pathogenic variant in MITF, a putative RCC gene [16]. This evidence concerns the gene BAP1 and renal cell adenocarcinoma.