In the same context, the IKZF1 R381C variant was reported to have DBA-like features, an immune-related gastrointestinal phenotype, and an alteration in hematopoietic gene expression networks, while mutations in the MPL proto-oncogene of the thrombopoietin (TPO) receptor have been linked to elevated TPO and a DBA-like phenotype [14,32]. Here, THPO is linked to Diamond-Blackfan anemia.