CRP and Crohn disease: Other factors that can lead to high clearance include male gender [5,12,18], induction compared to maintenance therapy [14,21,22], prior biologic therapy [13], an increased Crohn’s disease activity index (CDAI) [11], as well as elevated fecal calprotectin [10,11], C-reactive protein (CRP) [14,23,24] and erythrocyte sedimentation rate (ESR) [10].