The downregulated differential expression genes were predominantly associated with functions endopeptidase inhibitor activity, serine-type endopeptidase inhibitor activity, cadherin binding, and steroid hydroxylase activity [53], which might be linked with the inhibition of tumor cell invasion, migration, and metastasis [55], as well as cancer lipid metabolism, including in esophageal squamous cell carcinoma [56], which might explain the possible link between a high BMI and the decreased probability of esophageal cancer in the present study. This evidence concerns the gene CDH17 and cancer.