CCK and obesity due to melanocortin 4 receptor deficiency: When CB1 receptor activity is heightened, in the small-intestinal epithelium, the release of cholecystokinin-8 (CCK-8) is inhibited, resulting in delayed satiation and overeating (in diet-induced obesity) [104], highlighting the indirect control mechanism of endocannabinoids in gut–brain neurotransmission.