Our results show that the DH and VH respond unequally to the loss of FMRP, suggesting that FXS may be associated with distinct localized alterations even inside a particular brain structure; furthermore, our data point to the possibility that some changes occurring in the brain of subjects suffering from neurodevelopmental disorders may represent homeostatic processes that attempt to maintain the effectiveness of the neuronal network function. The gene discussed is FMR1; the disease is fragile X syndrome.