GDF-15 > 3393 pg/mL, NT-proBNP > 4060 ng/L, LA volume > 100 mL, mitral valve deceleration time (MV DT) ≤ 177.5 ms, E/E’ ratio > 14 predicted PH in patients with severe AS, helping stratify patients for earlier surgical treatment before the development of pulmonary hypertension [101]. The gene discussed is NPPB; the disease is aortic stenosis.