Giritharan et al. proposed to study serum biomarkers (BNP, Gal-3, GDF-15, sST2, osteoprotegerin, miRNA 19b and 21) with an echocardiographic parameter, GLS, in stratifying the risk in severe AS patients with type 2 diabetes mellitus [75]. This evidence concerns the gene NPPB and type 2 diabetes mellitus.