Later, in the study conducted by Vanella et al. [184], EA has been reported to decline activity/expression of different angiogenic factors in prostate cancer cells including heme oxygenase (HO), a potent modulator of cell growth and angiogenesis, VEGF, fibroblast growth factor (FGF), granulocyte colony-stimulating factor (G-CSF), and hepatocyte growth factor (HGF) expression. Here, HMOX1 is linked to Familial prostate cancer.