TP53 and urinary bladder cancer: Along with influencing the activity of proteins regulating the cell cycle, such as p53, p21, cyclins, cyclin-dependent kinases, and their regulators, EA also affects members of the Bcl-2 family under in vitro conditions in human bladder cancer T24 cells and in vivo in glioblastoma U87 cells in xenografted Balb/c nude mice [59,114].