Since androgens are crucial for functional status and psychological functions, we evaluated whether blood testosterone, androstenedione, or DHEA concentrations were associated with functional status and psychological alterations in patients with localised (PCa) or metastatic prostate cancer (mPCa) receiving ADT with analogues of luteinising hormone-releasing hormone (LHRH).<h4>Methods</h4>The five Fried criteria were considered to identify frailty syndrome. The gene discussed is GNRH1; the disease is posterior cortical atrophy.