Flow cytometric analysis revealed increased expression of programmed cell death protein (PD)-1, cytotoxic T lymphocyte-associated protein (CTLA)-4, CD160, and 2B4 (CD244/signaling lymphocytic activation molecule (SLAM) F4)) in the BM T-cells of MM patients, indicative of an immunosuppressive microenvironment favorable for immune evasion by MM cells [230]. This evidence concerns the gene CD160 and Miyoshi myopathy.