In an MM mouse model, the BM effector Killer Cell Lectin-Like Receptor (KLR)G1-NK cell subpopulation was substantially reduced with myeloma progression due to impaired chemokine receptor-ligand ratios with downregulation of CXCR-3 and CXCR-12 and increased CXCL-9 and CXCL-10 [258]. Here, KLRK1 is linked to Miyoshi myopathy.