Cytokines such as TGF-β, IL-10, IL-6, and prostaglandin-E2 (PGE2) secreted by MM cells promote MM cell proliferation and suppress NK cell activity through downstream signaling via STAT-3, which inhibits IFN-γ-mediated antibody-dependent cellular cytotoxicity (ADCC) and reduces the NK cell response to inflammatory cytokines such as IL-12 and IL-15 [256]. The gene discussed is TGFB1; the disease is Miyoshi myopathy.