Although there is no direct linkage published to date, we speculate that investigating potential DNA methylation abnormalities in ERVH48-1 has the potential to identify links with diseases of abnormal placentation, possibly including pregnancy-induced hypertension, preeclampsia, fetal growth restriction, and recurrent early pregnancy loss, making future investigation in this area essential. The gene discussed is ERVH48-1; the disease is hypertension, pregnancy-induced.