KIT and gastrointestinal stromal tumor: In this regard, Mühlenberg’s group observed that the histone deacetylase (HDAC) inhibitors (HDACi) SAHA and panobinostat (LBH589) hinder cell growth in KIT-positive (GIST-T1, GIST822, and GIST48) but not in KIT-negative cells (GIST62, GIST48B, and GIST522).