For instance, in the study by Zhu et al. on neonatal Sprague Dawley (SD) rats with hypoxic-ischemic encephalopathy (HIE), they demonstrated the neuroprotective mechanism of H19 in reducing autophagy through the miR-29b/Akt3/mTOR pathway [78]. The gene discussed is AKT3; the disease is perinatal asphyxia.