GSK3B and Alzheimer disease: However, there are various enzymes and receptors involved in the pathogenesis and progression of AD, including BACE-1, GSK-3β, CDK5, AChE, BuChE, MAO-A, MOA-B, NMDA, and ROCK2, that can be targeted therapeutically—either individually or collectively [10,11,12,13,14,15].