TLR4 and cardiovascular disorder: The carotenoid trans-lycopene (from tomato juice) alleviated the risk of aging-associated cardiovascular disease by reducing the concentration of important inflammatory molecules related to atherosclerosis [115], and lycopene showed protective effects in the learning and memory functional deficits of Aβ-induced Alzheimer’s disease rats by reducing the expression of toll-like receptor 4 (TLR4) and NF-κB p65 and the levels of TNF-α, IL-1β, and IL-6β in serum [116].