CDKN2A and intervertebral disk degenerative disorder: The senolytic compounds, dasatinib and quercetin, were found to prevent an age-dependent progression of disc degeneration in mice by preserving cell viability, phenotype, and matrix content via the regulation of the levels of cellular senescence markers p16INK4a and p19ARF; SASP molecules IL-6 and MMP13 [298]; and the natural plant polyphenols, curcumin and quercetin.