CAT and ischemic stroke: Hesperidin and neohesperidin, flavonoids present in citrus, enhance the content of glutathione (GSH) and the antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD) in animal models of ischemic stroke [176], and activates the Akt/Nrf2/HO-1 signaling pathway to inhibit oxidative stress and protect brain damage induced by cerebral artery occlusion [177].