For example, AD is treated with acetylcholinesterase inhibitors (donepezil, galantamine, and rivastigmine), which improves cholinergic neurotransmission [153], and/or the N-methyl-D-aspartate (NMDA) receptor antagonist memantine [154], which prevents excessive continuous activation of extrasynaptic NMDA receptors, reducing excitotoxicity [155]. This evidence concerns the gene ACHE and Alzheimer disease.