According to our current findings, 25(OH)D was independently linked to LVEF in univariate and multiple regression models, maintaining its significance even after correcting for important cardiovascular confounders, such as age, NT-proBNP, the presence of CCS, hypertension, and anemia (p = 0.036 and p = 0.030; p = 0.027 and p = 0.031). This evidence concerns the gene NPPB and hypertensive disorder.