Additionally, the osteoclastogenesis effects of miR-17-5p were effectively attenuated through inhibition of the PI3K/Akt pathway, suggesting that miR-17-5p promotes osteoclastogenesis through the PI3K/Akt pathway by targeting PTEN in NSCLC, which may be associated with osteolytic bone metastasis. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.