SUB1 and non-small cell lung carcinoma: For example, Li et al. [124] showed that hypoxic stress in NSCLC tumor cells suppresses tumor-secreted exosomal miR-101, which stimulates IL1A and IL6 expression in macrophages via targeting cyclin-dependent protein kinase 8 (CDK8) and SUB1 regulator of transcription (SUB1).