INS and major depressive disorder: Indeed, WBC is a safe and innovative method capable of applying precise and homogeneous “doses” of cold and inducing a rapid systematic reduction of inflammation and oxidative stress [58] with therapeutic effects on fatigue, pain, thymic tone, depression and sleep [24,25], as well as metabolic effects [29] such as increased thermogenesis and improved lipid profile, insulin sensitivity and glucose utilization, and could thus enhance the beneficial effects of an exercise program, especially one of short duration [59,60,61].