The MTOR rs11121704 C/T genotype was associated with increased odds of developing AMD under the codominant (OR = 1.74; CI: 1.23–2.46; p = 0.0067) and overdominant (OR = 1.63; CI: 1.17–2.27; p = 0.0038) models, and C/T+C/C genotypes were associated with 1.69-fold (OR = 1.69; CI: 1.21–2.35; p = 0.0018) increased odds of AMD according to the dominant model. This evidence concerns the gene MTOR and age-related macular degeneration.