In clear cell renal cell carcinoma, it was found that a low expression of miR-429, negatively correlated with the overexpression of CRKL, (v-crk sarcoma virus CT10 oncogene homolog (avian)-like) promoted the aggressiveness of cancer cells and advanced the clinical progression of ccRCC patients. The gene discussed is CRKL; the disease is nonpapillary renal cell carcinoma.