Huart et al. exposed A549 tumor cells to X-rays (5 Gy as opposed to 6 Gy γ-radiation used in this work) and the PARPi, olaparib (as opposed to talazoparib in this work), and observed significant TIS marked by SA-β-gal upregulation and CDKN1A increased expression. The gene discussed is CDKN1A; the disease is neoplasm.