The expression of L-R gene pairs including COL1A2-SDC4, COL1A2-SDC1, COL6A1-SDC1, COL6A2-SDC1, and COL1A1-ITGA2_ITGB1 was higher in sender and receiver cells derived from tumor tissue compared with those from normal tissue (Figure 5d). This evidence concerns the gene COL1A1 and neoplasm.