Genes including ANXA1 and PLAU in tumor cells were positively correlated with the cell proportion of Macro_APOE in CRC, and MDK expression was positively correlated with the cell proportion of Macro_ACP5 in PDAC (Figure 7b, Supplementary Table S7), suggesting tumor cells might contribute to macrophage polarization within the surrounding TME. Here, ACP5 is linked to colorectal carcinoma.