Furthermore, the gene expression levels of COL1A1 with SDC1, COL1A2 with SDC1, and COL6A3 with SDC1 were significantly positively correlated in TCGA-BC (Figure 5f) and TCGA-PDAC (Figure 6b), supporting their potential interaction in the surrounding tumor niche. Here, COL1A2 is linked to neoplasm.