PDCD1, TGFB1, CXCL8, CCL3, CCL4, and CCL5 were highly expressed in subTME-IS; CXCL2 and CXCL12 were highly expressed in subTME-ICI, which was consistent among cancer types (Supplementary Figure S10). This evidence concerns the gene CXCL2 and cancer.