The risk score of CRC subTME1 was calculated as follows: risk score = (−0.666 × DIAPH2) + (−0.654 × TNFRSF9) + (0.735 × SH3BGRL3) + (0.138 × RPS4Y1) + (0.771 × SLC11A2) + (1.210 × RPS4X) + (0.987 × NDUFA11) + (0.565 × SLC43A3) + (−1.506 × RER1) + (−1.576 × ACTG1) + (0.991 × FAM3C). The gene discussed is DIAPH2; the disease is colorectal carcinoma.