In a murine NASH model induced by supplying a combination of Western diet and the repeated administration of low doses of carbon tetrachloride, intravenous administration of conditioned medium from stem cells derived from human exfoliated deciduous teeth reduced liver fibrosis and inflammation, inhibited hepatocyte apoptosis and activation of inflammatory macrophages, and decreased pro-inflammatory and profibrotic mediators including TNF-α, TGF-β, and CCL-2 [159]. Here, TNF is linked to metabolic dysfunction-associated steatohepatitis.