Notably, a 2020 study conducted by Hierro-Bujalance et al. delved into the impact of empagliflozin, a representative drug from the SGLT2 inhibitor group, on vascular damage and impairment in a mixed murine model of Alzheimer’s disease and type 2 diabetes. The gene discussed is SLC5A2; the disease is early-onset autosomal dominant Alzheimer disease.