The transcriptional activity of the <i>protein tyrosine phosphatase non-receptor type 22 (PTPN22</i>) gene increased in all stages of the cancer, but the <i>p</i>-value was only less than 0.05 in CSIV vs. C. <i>Forkhead box O1 (FOXO 1</i>) and <i>ubiquitin B (UBB)</i> are statistically overexpressed in CSI. This evidence concerns the gene PTPN22 and cancer.