This synergistic interaction has serious adverse pathological effects: (1) it sustains upregulation of PI3K/Akt signalling, which increases further the anti-apoptotic potential of cancer cells; (2) it induces pro-invasive/metastatic gene expression; and (3) it halts the stress-induced cell cycle arrest in cancer cells [35,113,134]. Here, AKT1 is linked to cancer.