APOE and amyotrophic lateral sclerosis: In the present study, we have attempted to approach the microglial state in ALS by analyzing the expression of key genes related to the homeostatic state (TMEM119) or required for induction to the neurodegenerative DAM state according to previous descriptions (TREM2, APOE, TYROBP, CD33, MS4A, LPL, SPP1) [8].