It is possible that the DAM state is not enough to explain the functional complexity of the role of microglia in ALS, but we found it especially noteworthy that the genes related to the early-state DAM description [7,8,9] were overexpressed, and yet, we did not find differences in the genes related to late-state DAM (SPP1 and LPL), which could suggest a partial expression of the DAM program in ALS. The gene discussed is SPP1; the disease is amyotrophic lateral sclerosis.