Although the precise role of H19 in MCI has yet to be assessed and its role in Alzheimer’s Disease remains elusive, it was observed that in Aβ25-35-induced PC12 cells, lncRNA H19 negatively regulates the expression of the pro inflammatory cytokine HMGB1 by targeting miRNA miR-129 and acting as a sponge, consequently promoting inflammation, while its knockdown ameliorates inflammation and neurological function in rat models, making it a promising pharmacological target [38]. This evidence concerns the gene HMGB1 and Alzheimer disease.