PDE5A and benign prostatic hyperplasia: Similarly, other drugs used to treat BPH by reducing the smooth muscle tone include α-blockers (terazosin, doxazosin, tamsulosin, and alfuzosin) and PDE-5 inhibitors (PDE-5-Is) (Sildenafil, tadalafil, lodenafil, udenafil, and mirodenafil) [14,15].